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Selected Publication
Dual transposon sequencing profiles the genetic interaction landscape in bacteria

 Journal Article
 Justin J. Zik, Morgan N. Price, Keisha Hanifa Alma Mayra, Audrey A. Santoso, Adam P. Arkin, Adam M. Deutschbauer, Lok-To Sham
 Science, 389 (6767)
 2025

Leveraging the Capsular Polysaccharide Synthesis Pathway in Streptococcus pneumoniae as a Genetic Glycoengineering Platform

 Journal Article
 Cheryl Kang-Rou Wong, Ye-Yu Chun, Tong Su, Lok-To Sham
 ACS Bio & Med Chem Au, 5 (3)
 2025

Massively parallel barcode sequencing revealed the interchangeability of capsule transporters in Streptococcus pneumoniae

 Journal Article
 Wan-Zhen Chua, Rachel Lyn Ee Wong, Ye-Yu Chun, Nicole Ng Chyi Shien, Tong Su, Matthias Maiwald, Kean Lee Chew, Raymond Tzer-Pin Lin, Alyson M Hockenberry, Min Luo, Lok-To Sham
 Science Advances, 11 (4)
 2025

Rewiring the pneumococcal capsule pathway for investigating glycosyltransferase specificity and genetic glycoengineering

 Journal Article
 Tong Su, Wan-Zhen Chua, Yao Liu, Jingsong Fan, Si-Yin Tan, Dai-Wen Yang, Lok-To Sham
 Science Advances, 9 (36)
 2023

The divisome but not the elongasome organizes capsule synthesis in Streptococcus pneumoniae

 Journal Article
 Rei Nakamoto, Sarp Bamyaci, Karin Blomqvist, Staffan Normark, Birgitta Henriques-Normark, Lok-To Sham
 Nature Communications, 14 (1)
 2023

Influence of glycan structure on the colonization of Streptococcus pneumoniae on human respiratory epithelial cells

 Journal Article
 Ye-Yu Chun, Kai Sen Tan, Lisa Yu, Michelle Pang, Ming Hui Millie Wong, Rei Nakamoto, Wan-Zhen Chua, Amanda Huee-Ping Wong, Zhe Zhang Ryan Lew, Hsiao Hui Ong, Vincent T Chow, Thai Tran, De Yun Wang, Lok-To Sham
 Proceedings of the National Academy of Sciences (PNAS), 120 (13)
 2023

High-Throughput Mutagenesis and Cross-Complementation Experiments Reveal Substrate Preference and Critical Residues of the Capsule Transporters in Streptococcus pneumoniae

 Journal Article
 Wan-Zhen Chua, Matthias Maiwald, Kean Lee Chew, Raymond Tzer-Pin Lin, Sanduo Zheng, Lok-To Sham
 mBio, 12 (6)
 2021

The bacterial tyrosine kinase system CpsBCD governs the length of capsule polymers

 Journal Article
 Rei Nakamoto, Jeric Mun Chung Kwan, Jasmine Fei Li Chin, Hui Ting Ong, Josue Flores-Kim, Caroline Midonet, Michael S. VanNieuwenhze, Xue Li Guan, Lok-To Sham
 Proceedings of the National Academy of Sciences (PNAS), 118 (45)
 2021

Decoding capsule synthesis in Streptococcus pneumoniae

 Journal Article
 Tong Su, Rei Nakamoto, Ye-Yu Chun, Wan-Zhen Chua, Jia-Hui Chen, Justin J Zik, Lok-To Sham
 FEMS Microbiology Reviews, 45 (4)
 2021

Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways

 Journal Article
 Vicky Sender, Karina Hentrich, Anuj Pathak, Alicia Tan Qian Ler, Bethel Tesfai Embaie, Susanna L Lundström, Massimiliano Gaetani, Jan Bergstrand, Rei Nakamoto, Lok-To Sham, Jerker Widengren, Staffan Normark, Birgitta Henriques-Normark
 Proceedings of the National Academy of Sciences (PNAS), 117 (49)
 2020

Cell envelope defects of different capsule‐null mutants in K1 hypervirulent Klebsiella pneumoniae can affect bacterial pathogenesis

 Journal Article
 Yi Han Tan, Yahua Chen, Wilson H. W. Chu, Lok‐To Sham, Yunn‐Hwen Gan
 Molecular Microbiology, 113 (5)
 2020